Does resistant starch have an effect on intestinal modulation? An integrative review

Authors

  • Kemilly Laiz Barrionuevo Marzano
  • Bruna Vieira Nunes
  • Roberto Cesar Santos de Sousa
  • Jaciene Lopes de Jesus Assis
  • Ronielli Cardoso Reis
  • Eliseth de Souza Viana
  • Júlio Onésio Ferreira Melo
  • Renata Adriana Labanca
  • Raquel Linhares Bello de Araújo

DOI:

https://doi.org/10.55905/revconv.17n.3-251

Keywords:

microbiota, modulation intestinal, resistant starch

Abstract

Starch is a polysaccharide that is abundant in nature, composed of amylose and amylopectin. Resistant starch (RS) is a form that reaches the large intestine without complete digestion. By fermenting in the colon, RS provides carbon and energy to anaerobic bacteria, altering the microbiota and its metabolic activities. The gut microbiota influences physiological functions and human health. Resistant starch, similar to dietary fiber, increases short-chain fatty acids, triggering beneficial effects and modulating gut flora. However, in this integrative review, an overview of recent studies investigating the effect of resistant starch on intestinal modulation will be provided, with the following guiding question: Does resistant starch have a beneficial effect on the modulation of intestinal microbiota? The studies available in Portuguese and English, in the PubMed, Virtual Health Library (BVS) databases, were searched using an advanced search. The articles have shown that formulations containing resistant starch have a positive impact on intestinal modulation and the prevention or therapy of certain metabolic diseases. However, more insights are needed regarding resistant starch, in order to know which type of resistant starch and from which plant matrix has the best effect on health.

References

ABELL, Guy C.J. et al. Phylotypes related to Ruminococcus bromii are abundant in the large bowel of humans and increase in response to a diet high in resistant starch. FEMS Microbiology Ecology, v. 66, n. 3, p. 505–515, 2008.

BAI, Yunqiang et al. Resistant starch intake alleviates collagen-induced arthritis in mice by modulating gut microbiota and promoting concomitant propionate production. Journal of Autoimmunity, v. 116, n. September 2020, p. 102564, 2021. Disponível em: <https://doi.org/10.1016/j.jaut.2020.102564>.

BECKER, Anouck et al. Effects of Resistant Starch on Symptoms, Fecal Markers, and Gut Microbiota in Parkinson’s Disease — The RESISTA-PD Trial. Genomics, Proteomics and Bioinformatics, v. 20, n. 2, p. 274–287, 2022.

BELENGUER, Alvaro et al. Two routes of metabolic cross-feeding between Bifidobacterium adolescentis and butyrate-producing anaerobes from the human gut. Applied and Environmental Microbiology, v. 72, n. 5, p. 3593–3599, 2006.

BINDELS, Laure B.; WALTER, Jens; RAMER-TAIT, Amanda E. Resistant starches for the management of metabolic diseases. Current Opinion in Clinical Nutrition and Metabolic Care, v. 18, n. 6, p. 559–565, 2015.

BIRT, Diane F. et al. Resistant starch: Promise for improving human health. Advances in Nutrition, v. 4, n. 6, p. 587–601, 2013.

BRAHE, L. K.; ASTRUP, A.; LARSEN, L. H. Is butyrate the link between diet, intestinal microbiota and obesity-related metabolic diseases? Obesity Reviews, v. 14, n. 12, p. 950–959, 2013.

CASSETTARI, Vanessa Mello Granado et al. Combinations of laxatives and green banana biomass on the treatment of functional constipation in children and adolescents: a randomized study. Jornal de Pediatria, v. 95, n. 1, p. 27–33, 2019.

CHERBUY, Claire et al. Modulation of the caecal gut microbiota of mice by dietary supplement containing resistant starch: Impact is donor-dependent. Frontiers in Microbiology, v. 10, n. JUN, p. 1–11, 2019.

COSTA, Edna S. et al. Beneficial effects of green banana biomass consumption in patients with pre-diabetes and type 2 diabetes: A randomised controlled trial. British Journal of Nutrition, v. 121, n. 12, p. 1365–1375, 2019.

CROST, Emmanuelle H. et al. Mechanistic insights into the cross-feeding of Ruminococcus gnavus and Ruminococcus bromii on host and dietary carbohydrates. Frontiers in Microbiology, v. 9, n. NOV, p. 1–13, 2018.

DEMARTINO, Peter et al. Additional Resistant Starch from One Potato Side Dish per Day Alters the Gut Microbiota but Not Fecal Short-Chain Fatty Acid Concentrations. Nutrients, v. 14, n. 3, 2022.

DEMARTINO, Peter; COCKBURN, Darrell W. Resistant starch: impact on the gut microbiome and health. Current Opinion in Biotechnology, v. 61, p. 66–71, 2020. Disponível em: <https://doi.org/10.1016/j.copbio.2019.10.008>.

DOBRANOWSKI, Peter A.; STINTZI, Alain. Resistant starch, microbiome, and precision modulation. Gut Microbes, v. 13, n. 1, p. 1–21, 2021. Disponível em: <https://doi.org/10.1080/19490976.2021.1926842>.

FU, Jinfeng et al. Effects of Banana Resistant Starch on the Biochemical Indexes and Intestinal Flora of Obese Rats Induced by a High-Fat Diet and Their Correlation Analysis. Frontiers in Bioengineering and Biotechnology, v. 9, n. January, p. 1–14, 2021.

GONDALIA, Shakuntla V. et al. Substitution of Refined Conventional Wheat Flour with Wheat High in Resistant Starch Modulates the Intestinal Microbiota and Fecal Metabolites in Healthy Adults: A Randomized, Controlled Trial. Journal of Nutrition, v. 152, n. 6, p. 1426–1437, 2022.

GOPALSAMY, Geetha et al. Faecal Microbiota and Increases Microbial Diversity. Nutrients, p. 1–16, 2019.

HANES, Douglas et al. The gastrointestinal and microbiome impact of a resistant starch blend from potato, banana, and apple fibers: A randomized clinical trial using smart caps. Frontiers in Nutrition, v. 9, 2022.

HOFFMANN, A. Rodrigues et al. The Microbiome: The Trillions of Microorganisms That Maintain Health and Cause Disease in Humans and Companion Animals. Veterinary Pathology, v. 53, n. 1, p. 10–21, 2016.

HOMAYOUNI, Aziz et al. Resistant starch in food industry: A changing outlook for consumer and producer. Starch/Staerke, v. 66, n. 1–2, p. 102–114, 2014.

HOODA, Seema et al. 454 Pyrosequencing Reveals a Shift in Fecal Microbiota of Healthy Adult Men Consuming Polydextrose or Soluble Corn Fiber. Journal of Nutrition, v. 142, n. 7, p. 1259–1265, 2012. Disponível em: <https://doi.org/10.3945/jn.112.158766>.

HUGHES, Riley L. et al. Resistant starch type 2 from wheat reduces postprandial glycemic response with concurrent alterations in gut microbiota composition. Nutrients, v. 13, n. 2, p. 1–20, 2021.

KADYAN, Saurabh et al. Resistant starches from dietary pulses modulate the gut metabolome in association with microbiome in a humanized murine model of ageing. Scientific Reports, v. 13, n. 1, p. 1–14, 2023. Disponível em: <https://doi.org/10.1038/s41598-023-37036-w>.

KEMP, Julie Ann et al. The Impact of Enriched Resistant Starch Type-2 Cookies on the Gut Microbiome in Hemodialysis Patients: A Randomized Controlled Trial. Molecular Nutrition and Food Research, v. 65, n. 19, p. 1–9, 2021.

KLINGBEIL, Elizabeth A. et al. Potato-resistant starch supplementation improves microbiota dysbiosis, inflammation, and gut–brain signaling in high fat-fed rats. Nutrients, v. 11, n. 11, 2019.

KOAY, Yen Chin et al. Ingestion of resistant starch by mice markedly increases microbiome-derived metabolites. FASEB Journal, v. 33, n. 7, p. 8033–8042, 2019.

KOH, Ara et al. From dietary fiber to host physiology: Short-chain fatty acids as key bacterial metabolites. Cell, v. 165, n. 6, p. 1332–1345, 2016.

LEE, Hye Bin et al. Structural characteristics of resistant starch-enriched rice during digestion and its effects on gut barrier function in high-fat induced obese mice. Food Research International, v. 170, n. March, p. 113011, 2023. Disponível em: <https://doi.org/10.1016/j.foodres.2023.113011>.

LEI, Suzhen et al. Lotus seed resistant starch affects the conversion of sodium taurocholate by regulating the intestinal microbiota. International Journal of Biological Macromolecules, v. 186, n. June, p. 227–236, 2021. Disponível em: <https://doi.org/10.1016/j.ijbiomac.2021.07.031>.

LEY, Ruth E. et al. Obesity alters gut microbial ecology. Proceedings of the National Academy of Sciences of the United States of America, v. 102, n. 31, p. 11070–11075, 2005.

LI, Ping et al. Green Banana Flour Contributes to Gut Microbiota Recovery and Improves Colonic Barrier Integrity in Mice Following Antibiotic Perturbation. Frontiers in Nutrition, v. 9, n. March, p. 1–13, 2022.

LI, Zhi tao et al. In vitro digestion and fecal fermentation of highly resistant starch rice and its effect on the gut microbiota. Food Chemistry, v. 361, n. May, p. 130095, 2021. Disponível em: <https://doi.org/10.1016/j.foodchem.2021.130095>.

LIAN, Zhuoshi et al. Gut microbiota-derived melatonin from Puerariae Lobatae Radix-resistant starch supplementation attenuates ischemic stroke injury via a positive microbial co-occurrence pattern. Pharmacological Research, v. 190, n. February, p. 106714, 2023. Disponível em: <https://doi.org/10.1016/j.phrs.2023.106714>.

LIANG, Tingting et al. Metabolism of resistant starch RS3 administered in combination with Lactiplantibacillus plantarum strain 84-3 by human gut microbiota in simulated fermentation experiments in vitro and in a rat model. Food Chemistry, v. 411, n. June 2022, p. 135412, 2023. Disponível em: <https://doi.org/10.1016/j.foodchem.2023.135412>.

LOCKYER, S.; NUGENT, A. P. Health effects of resistant starch. Nutrition Bulletin, v. 42, n. 1, p. 10–41, 2017.

LUMENG, Carey N et al. Inflammatory links between obesity and metabolic disease Review series Inflammatory links between obesity and metabolic disease. v. 121, n. 6, p. 2111–2117, 2011.

MATHERS, John C. Dietary fibre and health - the story so far. Proceedings of the Nutrition Society, v. 1973, p. 120–129, 2023.

ROMANO, Renata Marino et al. Could Glyphosate and Glyphosate-Based Herbicides Be Associated With Increased Thyroid Diseases Worldwide? Frontiers in Endocrinology, v. 12, n. March, p. 1–14, 2021.

ROSADO, Carolyne Pimentel et al. Green banana flour supplementation improves obesity-associated systemic inflammation and regulates gut microbiota profile in mice fed high-fat diets. Applied Physiology, Nutrition and Metabolism, v. 46, n. 12, p. 1469–1475, 2021.

SALVATORE, Silvia et al. Dietary Fibers in Healthy Children and in Pediatric Gastrointestinal Disorders: A Practical Guide. Nutrients, v. 15, n. 9, p. 1–17, 2023.

SHIN, Na Ri et al. An increase in the Akkermansia spp. population induced by metformin treatment improves glucose homeostasis in diet-induced obese mice. Gut, v. 63, n. 5, p. 727–735, 2014.

SHINDE, Tanvi et al. Synbiotic supplementation with prebiotic green banana resistant starch and probiotic Bacillus coagulans spores ameliorates gut inflammation in mouse model of inflammatory bowel diseases. European Journal of Nutrition, v. 59, n. 8, p. 3669–3689, 2020. Disponível em: <https://doi.org/10.1007/s00394-020-02200-9>.

SONG, Eun Ji et al. Modulation of gut microbiota by rice starch enzymatically modified using amylosucrase from Deinococcus geothermalis. Food Science and Biotechnology, v. 32, n. 4, p. 565–575, 2023. Disponível em: <https://doi.org/10.1007/s10068-022-01238-1>.

SONNENBURG, Justin L; BÄCKHED, Fredrik. Diet – microbiota interactions as moderators of human metabolism. 2014.

TEICHMANN, June; COCKBURN, Darrell W. In vitro Fermentation Reveals Changes in Butyrate Production Dependent on Resistant Starch Source and Microbiome Composition. Frontiers in Microbiology, v. 12, n. April, p. 1–17, 2021.

TELESFORD, Kiel M. et al. A commensal symbiotic factor derived from Bacteroides fragilis promotes human CD39+Foxp3+ T cells and Treg function. Gut Microbes, v. 6, n. 4, p. 234–242, 2015.

TOPPING, David L.; CLIFTON, Peter M. Short-chain fatty acids and human colonic function: Roles of resistant starch and nonstarch polysaccharides. Physiological Reviews, v. 81, n. 3, p. 1031–1064, 2001.

WAN, Jiawei et al. Effects of Differences in Resistant Starch Content of Rice on Intestinal Microbial Composition. Journal of Agricultural and Food Chemistry, v. 69, n. 28, p. 8017–8027, 2021.

WANG, Anqi et al. Long-Term Consumption of Resistant Starch Induced Changes in Gut Microbiota, Metabolites, and Energy Homeostasis in a High-Fat Diet. Journal of Agricultural and Food Chemistry, v. 71, n. 22, p. 8448–8457, 2023.

WARMAN, Dwina Juliana; JIA, Huijuan; KATO, Hisanori. The Potential Roles of Probiotics, Resistant Starch, and Resistant Proteins in Ameliorating Inflammation during Aging (Inflammaging). Nutrients, v. 14, n. 4, 2022.

WU, Tsung Yen et al. Enhanced thermal stability of green banana starch by heat-moisture treatment and its ability to reduce body fat accumulation and modulate gut microbiota. International Journal of Biological Macromolecules, v. 160, p. 915–924, 2020. Disponível em: <https://doi.org/10.1016/j.ijbiomac.2020.05.271>.

XIAO, Han; KANG, Sona. The Role of the Gut Microbiome in Energy Balance With a Focus on the Gut-Adipose Tissue Axis. Frontiers in Genetics, v. 11, n. April, p. 1–12, 2020.

XU, Jiangbin et al. A more pronounced effect of type III resistant starch: Vs. type II resistant starch on ameliorating hyperlipidemia in high fat diet-fed mice is associated with its supramolecular structural characteristics. Food and Function, v. 11, n. 3, p. 1982–1995, 2020.

XU, Tao et al. Tuber flours improve intestinal health and modulate gut microbiota composition. Food Chemistry: X, v. 12, p. 100145, 2021. Disponível em: <https://doi.org/10.1016/j.fochx.2021.100145>.

YACHIDA, Shinichi et al. Metagenomic and metabolomic analyses reveal distinct stage-specific phenotypes of the gut microbiota in colorectal cancer. Nature Medicine, v. 25, n. 6, p. 968–976, 2019. Disponível em: <http://dx.doi.org/10.1038/s41591-019-0458-7>.

YOSHIDA, Naofumi et al. Effect of Resistant Starch on the Gut Microbiota and Its Metabolites. p. 705–719, 2019.

ZAMAN, Siti A.; SARBINI, Shahrul R. The potential of resistant starch as a prebiotic. Critical Reviews in Biotechnology, v. 36, n. 3, p. 578–584, 2016. Disponível em: <http://dx.doi.org/10.3109/07388551.2014.993590>.

ZENG, Hongliang et al. Gut microbiota-metabolic axis insight into the hyperlipidemic effect of lotus seed resistant starch in hyperlipidemic mice. Carbohydrate Polymers, v. 314, n. December 2022, p. 120939, 2023. Disponível em: <https://doi.org/10.1016/j.carbpol.2023.120939>.

ZHANG, Bin; DHITAL, Sushil; GIDLEY, Michael J. Densely packed matrices as rate determining features in starch hydrolysis. Trends in Food Science and Technology, v. 43, n. 1, p. 18–31, 2015. Disponível em: <http://dx.doi.org/10.1016/j.tifs.2015.01.004>.

ZHANG, Lei et al. Metabolic phenotypes and the gut microbiota in response to dietary resistant starch type 2 in normal-weight subjects: a randomized crossover trial. Scientific Reports, v. 9, n. 1, p. 1–11, 2019.

ZHANG, Yawen et al. Dietary type 2 resistant starch improves systemic inflammation and intestinal permeability by modulating microbiota and metabolites in aged mice on high-fat diet. v. 12, n. 10, p. 9173–9187, 2020. Disponível em: .

Downloads

Published

2024-03-20

How to Cite

Marzano, K. L. B., Nunes, B. V., Sousa, R. C. S. de, Assis, J. L. de J., Reis, R. C., Viana, E. de S., Melo, J. O. F., Labanca, R. A., & Araújo, R. L. B. de. (2024). Does resistant starch have an effect on intestinal modulation? An integrative review. CONTRIBUCIONES A LAS CIENCIAS SOCIALES, 17(3), e5642. https://doi.org/10.55905/revconv.17n.3-251